A recent study regarding obesity has made shocking revelations. This study has challenged the connection between obesity and heart diseases. It is generally believed that obesity increases the risk of heart disease and high cholesterol, but a recent research has revealed that a gene named MC4R, which is responsible for increasing obesity, also protects against heart diseases.
Research has found that in people who have a rare variant of the MC4R gene, the level of LDL i.e. bad cholesterol reduces and the risk of heart disease also reduces. According to scientists, this gene is found in about one percent of obese people and five percent of obese children. According to this research, this gene mutation may occur in one out of every 300 people in Britain.
Unique connection between obesity and heart disease
Actually, the purpose of this research was to understand how some people remain safe from heart diseases despite being obese. In this study conducted under the metabolism experts of the University of Cambridge, it has been found that the MC4R gene produces a protein in our brain that controls appetite. When this gene works properly, the person eats less. But when there is a disturbance in it, the person feels more hungry and weight increases rapidly. According to researchers, this gene causes obesity, but people with its rare variant have significantly lower levels of bad cholesterol, which reduces the risk of heart disease.
Investigation conducted on thousands of people
In the study, research was done on the genes of 7,719 children and 124 adults, in whom obesity was due to the disorder of MC4R gene. Apart from this, they were compared with 3.36 lakh people of UK Bio Bank. The results of which revealed that people with MC4R deficiency had better blood pressure and cholesterol profiles and their heart health was found to be better than that of the general population.
What does the report say?
The results of this research show that the MC4R gene controls the fat metabolism of the body through the brain. In people in whom this gene does not function properly, obesity increases, but the level of triglyceride and bad cholesterol remains low. Regarding this research, researchers say that by understanding the functioning of MC4R gene, new medicines can be made for the treatment of heart diseases and high cholesterol.
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Disclaimer: This information is based on research studies and expert opinion. Do not consider this as a substitute for medical advice. Before adopting any new activity or exercise, please consult your doctor or relevant specialist.
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