10 Jun 2025, Tue

Stress in Childhood Can Affect Brain: According to a new research, stress and difficult experiences in childhood can have a profound effect on mental health. The trauma in childhood can have a permanent effect on the brain. Even it can become the cause of mental disorders. This research suggests that childhood difficulties bring permanent changes in brain structure and immunity, which increases the risk of depression, bipolar disorder and other mental illnesses.

Sara Polyt, a senior researcher at Italy’s Milan (IRCCS) Ospedale San Raffel, said, “The immune system does not just fight infection, but it also plays an important role in shaping our mental health.” He said that childhood stress changes this system, which increases the risk of mental illnesses after decades. Research has identified those special inflammatory indicators (inflammatory markers) who are associated with childhood stress.

Mood disorder is the main cause of disease and death

The research published in the journal ‘Brain Medicine’ has given attention to the use of immunomodulatory agent (Interlucin 2) for the treatment of mood disorder (other mental disorders). According to the World Health Organization, mood disorder is the leading cause of disability, disease and death worldwide. The rate of depression in future can be about 12 percent and bipolar disorder up to 2 percent.

Research found that the mood disorder plays an important role in the immune system disturbances, especially the inflammatory response system. This disturbance can become a major cause of these disorders. Research found that inflammatory indicators (inflammatory markers), which are associated with childhood stress, can form the basis for developing new and better treatment of mental illnesses in future. These indicators will help doctors understand how to treat the disease.

Reduce the risk of mental illnesses

Sara Polati says that she wants to understand the relationship between the immune system and the environment. Their goal is to develop such prevention strategies that reduce the risk of mental illnesses especially in stressed childhood. This research is a major step towards understanding psychiatric care and focusing on prevention.

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