17 Dec 2025, Wed

Vitamin B12 Deficiency Skin Symptoms: Sometimes some changes seen on the skin are not just a cosmetic problem, but can also be a sign of some problem going on inside the body. Recent research has revealed that the skin condition acanthosis nigricans may be linked to the risk of type 2 diabetes, especially in young people. The study included young overweight people who had symptoms of AN on their skin through a case-control analysis. According to research, the risk of type-2 diabetes in participants who had AN was found to be almost double compared to those obese people who did not have AA. It also became clear from the study that EN was the main cause of insulin resistance in these people.

What came out in the research

Data from the National Library of Medicine revealed that the severity of AN around the neck was directly linked to fasting insulin levels and insulin resistance test results. In such cases, doctors recommend getting tests related to blood sugar and insulin done, so that the problem can be detected in time. However, it is not necessary that every time darkening of the skin is related to diabetes. In some cases it may also be due to deficiency of Vitamin B12. Medical reviews show that hyperpigmentation caused by B12 deficiency can appear on the face, palms, and skin folds, sometimes resembling hormonal problems.

Problem due to B12 deficiency

With B12 deficiency, symptoms like fatigue, numbness or tingling in hands and feet, pain in the tongue and yellowing of the skin can also be seen. If a person has sudden darkening of skin folds, eats a mostly plant-based diet, or has digestive problems, doctors usually get B12 levels checked. In some people, blackening of elbows or knees also occurs due to continuous rubbing or pressure. Sitting in the same position for a long time, repeatedly resting elbows on a hard surface or sitting on knees increases friction on the skin. Due to this, melanin starts getting produced more and the skin becomes thick and dry. This type of darkening is usually not velvety and does not extend to the neck or armpits.

What do experts say

According to experts, in such cases, using creams containing lactic acid and urea for several months exfoliates the upper layer of the skin and the complexion may become lighter. Along with this, moisturizing and avoiding constant pressure on the elbows is also important. Apart from this, dark spots can also remain after inflammatory skin diseases like eczema, psoriasis or contact dermatitis, which is called post-inflammatory hyperpigmentation, in such cases it is necessary to treat the inflammation first, then moisturizer and sun protection are adopted as maintenance.

When should one see a doctor?

If the darkening of the skin starts spreading rapidly, becomes very thick or itchy, or is accompanied by symptoms such as weight loss, weakness and stomach pain, a doctor should be contacted immediately. In some rare cases, the sudden and severe appearance of EN may also be associated with internal cancer, especially in the elderly. According to the CDC, acanthosis nigricans is a common skin condition associated with diabetes. Therefore, people who show symptoms should definitely get their blood sugar and insulin resistance checked, so that serious diseases can be avoided in time.

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Disclaimer: This information is based on research studies and expert opinion. Do not consider this as a substitute for medical advice. Before adopting any new activity or exercise, please consult your doctor or relevant specialist.

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