By Admin 
Heart attack medicine: America’s Food and Drug Administration has recently approved a medicine named Rybelsus. This is the first oral GLP-1 receptor agonist drug, which can now be used to reduce the risk of heart disease in adults. Till now this medicine was given for the treatment of type-2 diabetes, but now it can also be used to prevent heart attack, stroke and other heart problems. This means that now people will not have to get injections. It is a needle-free method that protects the heart and blood vessels from inflammation and oxidative stress. Besides, it also helps in blood sugar and weight control. This decision is being considered a major progress in heart care. Let us tell you about how it works.
How does Rybelsus work?
Rybelsus is one of the drugs called GLP-1 receptor agonists. These medicines work like the GLP-1 hormone produced in the body. This hormone helps in controlling blood sugar, managing appetite and keeping digestion better. But its specialty is not limited to diabetes only. Research has shown that it also provides protection to the heart and blood vessels.
There are two major causes of heart attack, oxidative stress and inflammation of the arteries. It reduces both of these and keeps the inner layer of blood vessels healthy so that blood flow remains smooth and the risk of blood clot formation is reduced.
Research suggests that GLP-1 receptor agonists make platelets less sticky, which reduces the risk of blockage in arteries. Apart from this, this medicine reduces LDL and triglycerides. It also has a mild diuretic effect, which helps in maintaining water balance in the body. Therefore it is also beneficial for people with heart failure or high blood pressure.
What is the difference?
The name Rybelsus is new, but Semaglutide was already available in injectable form under the name Ozempic. The effect of both is almost the same, the only difference is in the way of delivery. The injected medicine goes directly into the bloodstream, due to which the effect is quicker and stomach-related side effects are reduced.
Whereas Rybelsus is a tablet, which passes through the digestion system and liver, hence some part of it gets broken down before reaching the body. For this reason it has to be taken in slightly larger quantities. In the beginning, some people may have problems like nausea, flatulence or loss of appetite, but this usually gets cured in a few days.
Why is FDA approval important?
This step of FDA is being considered as a big change in heart health. Till now, lifestyle changes, cholesterol-lowering medicines like statins and blood pressure medicines played the main role in the treatment of heart disease. But now GLP-1 based medicines target metabolic disturbances and inflammation, the real causes of heart disease. Persistent inflammation is now considered to be the cause of atherosclerosis, i.e. accumulation of fat in the arteries, which increases the risk of heart attack and stroke. Ribelsus reduces this inflammation and protects blood vessels from damage, thereby slowing down the rate of plaque formation.
What was found in the research?
A study “Clinical Trial of Rybelsus (Semaglutide) Among Adults With Alcohol Use Disorder (AUD)” published in the National Library of Medicine found that GLP-1 receptor agonists significantly reduce the risk of heart attack, stroke, and heart-related death. Earlier this effect was seen in the injection form, and now Rybelsus is also showing similar results when taken continuously as per doctor’s advice.
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Disclaimer: This information is based on research studies and expert opinion. Do not consider this as a substitute for medical advice. Before adopting any new activity or exercise, please consult your doctor or relevant specialist.
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