Weight loss medicine: Sun Pharma’s new drug utriglutide, which is being developed to treat obesity and type-2 diabetes, has shown significant weight loss and metabolic improvements in post-menopausal women in early clinical studies. The results of the Phase 1a/2b trial of this drug were presented this week in the scientific session of the American Heart Association (AHA) held in New Orleans, USA. Utriglutide belongs to the same drug group as the world famous Monzaro and Vigovi. The specialty of these medicines is that they have become increasingly popular in India also. These medicines are GLP-1 receptor agonists, which work like liver hormones to reduce appetite.

What came out in the trial?

According to Sun Pharma, apart from weight loss, the drug showed improvement in several biomarkers related to systolic blood pressure, liver fat, and insulin sensitivity. Along with this, serum uric acid also reduced, which shows that the drug can affect many aspects of metabolic problems. Sun Pharma Chairman Dilip Shanghvi said, “Obesity and metabolic liver disease are on the rise, especially in post-menopausal women. The results of this initial study are encouraging and move us towards developing better treatments to combat these diseases.”

increasing problem

India’s anti-obesity drug market is currently worth Rs 3,000 to Rs 3,500 crore, which is expected to increase to Rs 25,000 crore by 2030. This was speculated to be due to the increasing problem of obesity and lifestyle diseases.

Study results give hope

This trial included post-menopausal women aged 52 to 69 years, who were suffering from obesity. After taking the drug for 14 weeks, those taking utriglutide lost an average of 8 percent weight and this continued until the 17th week. Those taking placebo lost only 2.1 percent and 1.2 percent weight, respectively.

What was seen till the 14th week?

• 76 percent women lost more than 5 percent weight.
• 25 percent women lost more than 10 percent weight.
• The average BMI initially was 43, which decreased to 39.7 to 39.8 by weeks 14 and 17.

The most important thing during this period was that there was a 28.6 percent reduction in liver fat, whereas only a 2.7 percent reduction was seen in the placebo group. These results show that this medicine can be helpful in problems like obesity as well as MASLD metabolic liver disease.

Side effect

If we talk about its side effects, they included loss of appetite, early fullness, nausea, indigestion and vomiting. Which are considered common among GLP-1 drugs. Dr. Rohit Loomba (UC San Diego), who was associated with the trial, said, “Utriglutide has shown significant improvement in liver fat and several metabolic parameters in women with obesity and MASLD, which is very encouraging.” If everything is approved after the trial, then this medicine can enter the market soon.

Read this also: World Diabetes Day 2025: Even if you don’t eat sweets, sugar level is increasing, know which habits increase the risk of diabetes?

Disclaimer: This information is based on research studies and expert opinion. Do not consider this as a substitute for medical advice. Before adopting any new activity or exercise, please consult your doctor or relevant specialist.

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Weight Loss Drugs: Amidst the rapidly increasing obesity in India, the trend of weight loss medicines has also increased. Instead of gym and dieting, people are now taking the help of such medicines which help in reducing weight. However, doctors are constantly warning about the side effects of these medicines. In such a situation, let us know today which medicines are being used for weight loss in India, along with which are the most dangerous medicines?

Most of Objeta-60 Capsules

Objeta-60 Capsule is one of the most commonly used medicines to reduce obesity. This medicine prevents the absorption of fat in the body, which reduces calorie intake and gradually leads to weight loss. This medicine is taken with food or within 1 hour of food during the day. Doctors believe that if it is taken with regular exercise and a balanced diet, its results are better. However, it also has many side effects. The use of this medicine may cause problems like stomach ache and diarrhea in many people. In some cases, gas problems may also occur. Taking this medicine for a long time without doctor’s advice can be more dangerous.

Mounjaro and Zepbound

American company Eli Lilly’s drugs Monjaro and Zepbound were recently approved in India for weight loss and diabetes control. The chemical name of both these medicines is Tirzepatide. This medicine is given in the form of injection which controls insulin in the body and also reduces appetite. According to doctors, this medicine activates GLP-1 and GIP hormones in the body, due to which the person feels full and eats less. At the same time, this medicine can also have many side effects. Taking this medicine includes problems like vomiting, nausea, dizziness and low blood sugar level. Apart from this, this claim can prove to be very dangerous for people who have a history of thyroid cancer.

Vegovi recently launched drug

Vegovi drug manufactured by Danish company Novo Nordisk was also recently launched in India. This medicine is given in the form of injection to reduce weight in severe cases of obesity. This medicine activates the appetite suppressing hormone GLP, due to which the person eats less and gradually starts losing weight. This medicine can also have many side effects, which include vomiting, nausea, stomach pain and gas problems.

Balloon Capsule Treatment

Now people are also turning to balloon capsule treatment for weight loss. It is a capsule which swells like a balloon after entering the stomach and reduces the space in the stomach. Due to this the person eats less food and starts losing weight. It is used through endoscopy or swallow pill method. However, this method is expensive, its one-time treatment costs between Rs 2.5 lakh to Rs 4 lakh. At the same time, this treatment is not for those people who have problems with heartburn or reflexes.

Which medicine is the most dangerous?

According to doctors, medicines like Monjaro, Zepbound and Vegovi are effective, but their side effects can be more serious than other medicines. If they are used without doctor’s supervision, there can be major problems related to blood sugar level, thyroid and digestion in the body. In many cases, more serious problems can also be seen due to these medicines.

Also read- Wrong eating habits can affect eyesight, avoid these things today itself.

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