Pancreas cancer is counted among the most dangerous and deadly cancers in the world. This disease progresses so silently that by the time its symptoms are clearly visible, it is often too late. This is the reason why about 90 percent of patients suffering from this cancer die within five years.

This cancer has remained a big challenge for doctors and scientists for a long time. Neither is it detected early nor are there very effective options for its treatment. But now, after several decades of despair, some new research has shown a new light of hope. In recent years, scientists have been trying to understand how to prepare the body’s own immune system in such a way that it can fight cancer on its own. In this direction, enthusiasm has increased regarding treatment based on vaccine and immunotherapy.

Successful experiment on rats, hope for humans

Spanish scientists have recently developed a new combination therapy method, which completely eliminated pancreas cancer tumors from the body of rats in the laboratory. Although this research has not yet been tried on humans, its results are so positive that scientists have started feeling that in future this method can help in saving the lives of patients.

Earlier, in America too, scientists had conducted initial human trials of mRNA-based personalized pancreas cancer vaccine, in which good results were seen in some patients. These two studies together have indicated that vaccine-based treatment can bring a big change in the future.

How does this new therapy work?

This study conducted in Spain was conducted by scientist Mariano Barbaside and his team from the Spanish National Cancer Research Center (CNIO). This treatment is not based on any one medicine, rather three different methods have been used together. The first of which is advanced immunotherapy, through which the body’s immune system is strengthened. After this, the second cancer vaccine, which teaches the immune system to recognize cancer cells.

The third one is checkpoint inhibitors, which remove the brakes on the immune system and allow it to freely fight cancer. By combining these three, scientists broke the protective shield around the cancer, so that T-cells could attack the cancer and the tumor could not return. Experts believe that using more than one method together makes treatment more effective than giving only one medicine.

Statistics show the seriousness of the disease

According to the World Health Organization’s cancer agency, about 5.1 lakh new cases of pancreas cancer were reported worldwide in 2022. In the same year, about 4.6 lakh people died due to this cancer. The situation is worrying in India also. 13,661 new patients and 12,759 deaths were recorded here. These figures clearly show how quickly this cancer kills.

KRAS gene and the problem of drug resistance

In about 90 percent of pancreas cancer cases, a gene called KRAS is defective (mutated). For a long time, no drug was available that could target this gene. For about 50 years, treatment mainly depended on chemotherapy. In 2021, drugs targeting KRAS were approved for the first time, but the problem was that within a few months the tumor developed resistance against those drugs.

Barbasid and his team found a unique solution to this problem. They blocked the KRAS signaling pathway at not one, but three different places. Although the results are very encouraging, the scientists themselves are cautious. Barbacid has clearly said that we are not yet ready to try this triple therapy on humans. He said that more research, safety testing and preparation is needed before starting human trials.

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Disclaimer: This information is based on research studies and expert opinion. Do not consider this as a substitute for medical advice. Before adopting any new activity or exercise, consult your doctor or relevant specialist.

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The Covid vaccine, which helps in defeating Covid-19 during the Corona epidemic, may now emerge in a new form. In fact, new research has revealed that the mRNA vaccine of Covid-19 not only fights the virus, but can also play an important role in the treatment of cancer. How did this become possible and how much truth is there in these claims? Let us know.

This thing came to light in research

A study revealed that patients who took mRNA vaccine along with immunotherapy for lung cancer or melanoma (a type of skin cancer), their life expectancy almost doubled. This means that patients who were undergoing immunotherapy after taking the mRNA vaccine lived for an average of 37.3 months. At the same time, the average age of those who did not take the vaccine was 20.6 months. This shows that mRNA technology can help the body’s immune system fight tumors, raising new hopes for cancer treatment.

Cancer treatment and miracle of mRNA vaccine

A study by MD Anderson Cancer Center in Texas and the University of Florida looked at data from more than 1,000 patients who had severe lung cancer or melanoma. Research found that patients who took an mRNA Covid vaccine (such as Pfizer or Moderna) within 100 days of starting immunotherapy had twice the survival rate of those without the vaccine.

How effective is this vaccine?

According to Dr. Adam Grippin, Senior Resident in Radiation Oncology, this study shows that the mRNA vaccine of Covid can prepare the body’s immune system to fight cancer. When it is taken with immune checkpoint inhibitors (a type of immunotherapy), it gives a good response against cancer, significantly increasing the survival of patients.

How does mRNA vaccine work?

The results of this study were presented at the 2025 European Society for Medical Oncology (ESMO) conference and published in the journal Nature. Researchers say that mRNA vaccine activates the immune system in the body, making it easier to eliminate cancer cells. This vaccine increases interferons and other immune molecules, which increase PD-L1 protein in tumors. With this, the immune system is able to easily identify and destroy cancer cells.

New path in cancer treatment

This discovery has raised hopes of further improving cancer treatment. Incorporating mRNA vaccine into existing cancer therapy can increase the effect of treatment and prolong the life of patients. This shows the power of mRNA technology, which can be helpful in fighting not only Covid but also serious diseases like cancer. Scientists are now doing more research in this direction, so that cancer patients can get better treatment.

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Disclaimer: This information is based on research studies and expert opinion. Do not consider this as a substitute for medical advice. Before adopting any new activity or exercise, please consult your doctor or relevant specialist.

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Russia has claimed to have achieved great success against a deadly disease like cancer. Scientists there have prepared a new MRNA-based cancer vaccine “Enteromix”, which has shown 100 percent effective results in early pre-clinical trials. It is being claimed that this vaccine may change the direction of treating cancer in the coming time. Currently, it is being prepared for trial on humans. Let us tell you about it.

Why is this discovery special?

Cancer is one of the biggest causes of death worldwide. According to WHO, every year about 1 crore people lose their lives from cancer. So far, treatment such as chemotherapy and radiation damages not only cancer cells but also healthy cells. At the same time, this new Russian vaccine makes the body’s immunity so strong that it only attacks cancer cells.

How does the vaccine work?

Enteromix is ​​a personalized MRNA vaccine. That is, it is made on the basis of genetic information of every patient’s tumor. AI technology is used in this. Scientists can design the patient according to the patient in a few hours. This vaccine “trains” the body’s immune system so that it can recognize cancer cells and eliminate them.

How are the initial results?

According to Sputnik, the Federal Medical and Biological Agency (FMBA) has announced that it has been successful in MRNA-based vaccine pre-clinical trials. The agency’s chief Veronica Squortsova said that the vaccine has shown not only security but also effectiveness. The report states that this vaccine has given significant results in shortening the tumor and slowing their growth. The most important thing is that it is also considered safe for repeated use. Squortsova further stated that this vaccine will be prepared differently for every patient and it will be customized on the basis of their RNA profile. The first variant of this vaccine will be used to treat colorectal cancer. In addition, the second variant is being developed for glioblastoma (brain cancer) and certain types of melanoma (skin cancer).

St. Petersburg International Economic Forum (Spief 2025), which took place from 18 to 21 June in St. Petersburg, the northern city of Russia, while the clinical trial of this vaccine was announced. The event was organized by the Roskongres agency under the Russian President’s office, showing the progress in Russia’s medical research and biotechnology.

According to the report of the presspath, the entrance vaccine uses four safe viruses, which destroy them by directly attacking cancer tumors and also strengthens the immune system, so that the body itself can fight the disease. This vaccine has proved to be very effective after the tests conducted for many years. The report states that it has slowed the growth of cancer tumors and in some cases even the tumor has completely eliminated. Now that the trials are successfully completed, only regulatory approval (government approval) remains. If it is approved, the entrances can become the world’s first personalized MRNA cancer vaccine, which will be available to the common people.

Success rate and challenges

In reports, the success rate of the vaccine is said to be 100 percent, but experts say that this is just the initial results. The real impact will be detected only after trial on humans. Therefore, it is too early to call it a “final treatment” of cancer. The Russian government has said that after the trial is successful, this vaccine will be given free to citizens. However, the estimated price of one of its doses is said to be around 24–25 thousand rupees (300,000 rubles). Russia’s new MRNA cancer vaccine can prove to be a major change for Enteromix Medical Science. If it is equally effective on humans, then it can become a game-changer in the treatment of cancer. The whole world’s eyes are on the trials to be held in the coming months.

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Disclaimer: This information is based on the opinion of research studies and experts. Do not consider it an alternative to medical advice. Before adopting any new activity or exercise, consult your doctor or concerned specialist.

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