Weight loss medicine: Sun Pharma’s new drug utriglutide, which is being developed to treat obesity and type-2 diabetes, has shown significant weight loss and metabolic improvements in post-menopausal women in early clinical studies. The results of the Phase 1a/2b trial of this drug were presented this week in the scientific session of the American Heart Association (AHA) held in New Orleans, USA. Utriglutide belongs to the same drug group as the world famous Monzaro and Vigovi. The specialty of these medicines is that they have become increasingly popular in India also. These medicines are GLP-1 receptor agonists, which work like liver hormones to reduce appetite.

What came out in the trial?

According to Sun Pharma, apart from weight loss, the drug showed improvement in several biomarkers related to systolic blood pressure, liver fat, and insulin sensitivity. Along with this, serum uric acid also reduced, which shows that the drug can affect many aspects of metabolic problems. Sun Pharma Chairman Dilip Shanghvi said, “Obesity and metabolic liver disease are on the rise, especially in post-menopausal women. The results of this initial study are encouraging and move us towards developing better treatments to combat these diseases.”

increasing problem

India’s anti-obesity drug market is currently worth Rs 3,000 to Rs 3,500 crore, which is expected to increase to Rs 25,000 crore by 2030. This was speculated to be due to the increasing problem of obesity and lifestyle diseases.

Study results give hope

This trial included post-menopausal women aged 52 to 69 years, who were suffering from obesity. After taking the drug for 14 weeks, those taking utriglutide lost an average of 8 percent weight and this continued until the 17th week. Those taking placebo lost only 2.1 percent and 1.2 percent weight, respectively.

What was seen till the 14th week?

• 76 percent women lost more than 5 percent weight.
• 25 percent women lost more than 10 percent weight.
• The average BMI initially was 43, which decreased to 39.7 to 39.8 by weeks 14 and 17.

The most important thing during this period was that there was a 28.6 percent reduction in liver fat, whereas only a 2.7 percent reduction was seen in the placebo group. These results show that this medicine can be helpful in problems like obesity as well as MASLD metabolic liver disease.

Side effect

If we talk about its side effects, they included loss of appetite, early fullness, nausea, indigestion and vomiting. Which are considered common among GLP-1 drugs. Dr. Rohit Loomba (UC San Diego), who was associated with the trial, said, “Utriglutide has shown significant improvement in liver fat and several metabolic parameters in women with obesity and MASLD, which is very encouraging.” If everything is approved after the trial, then this medicine can enter the market soon.

Read this also: World Diabetes Day 2025: Even if you don’t eat sweets, sugar level is increasing, know which habits increase the risk of diabetes?

Disclaimer: This information is based on research studies and expert opinion. Do not consider this as a substitute for medical advice. Before adopting any new activity or exercise, please consult your doctor or relevant specialist.

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Nowadays, obesity and excess weight gain have become a common problem, but after menopause this problem becomes even more serious. According to a recent study, overweight or obesity in women after menopause increases the risk of breast cancer. Actually, after menopause, the level of estrogen in the body of women decreases, in such a situation when the ovaries stop producing the hormone, the body starts producing it from fat tissue. If there is excess fat in the body then estrogen level also increases abnormally. This extra estrogen promotes the growth of breast cells which can later turn into cancer.

Risk of obesity and heart disease increases

According to a report by the World Health Organization, the risk of breast cancer increases significantly in women suffering from high BMI and heart disease. In this research, data of about 1.68 lakh women from Europe and Britain has been analyzed. When the study was started, none of them had cancer, diabetes or heart disease, but after about 11 years of follow-up, 6,793 women developed breast cancer after menopause. This research revealed that in women whose BMI was more than 25 and who were already suffering from heart-related diseases, this risk was found to be increased by 31 percent. According to this research, this risk was found to be increased by 13 percent in women who were not already suffering from heart related diseases.

How does body fat increase the risk of breast cancer?

According to the American Cancer Society, after menopause, the ovaries stop producing estrogen. In this condition, the fat tissue of the body becomes the main source of estrogen. Therefore, the more fat there is in the body, the more the level of estrogen increases. At the same time, this increased hormone activates the breast cells again and again, which leads to the growth of abnormal cells. This process can later lead to breast cancer. Obesity also increases insulin resistance. When the body is unable to use insulin properly, its level in the blood increases. At the same time, high insulin levels have also been linked to many types of cancer like breast cancer.

How can we protect ourselves?

1. Keep weight under control- Obesity is the root of many diseases, that is why it is important to maintain a healthy BMI.
2. Do regular exercise- Women should walk, walk or exercise for at least 150 minutes a week.
3. Avoid alcohol and smoking- Women should avoid things like alcohol and smoking, because both of them increase hormonal imbalance.
4. Take healthy food- Women should stay away from processed food, sweet drinks and oily food items. So that weight remains under control.

Read this also – Delhi’s pollution is entering the blood and causing swelling in the veins, the common man is slowly coming closer to death!

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