Early Signs Of Ovarian CancerOvarian cancer is the third most common gynecological cancer in the world and one of the leading causes of cancer death among women in the United States. It is often called a silent killer, because in the initial stages it grows almost without making any noise and by the time it is detected, the disease has progressed significantly. According to global data for the year 2024, about 3.24 lakh new cases occurred in the world and about 2.06 lakh women died due to this disease.
In most cases, this cancer starts from a malignant tumor forming in the ovary. Especially epithelial ovarian cancer, which is caused by rapid growth of abnormal cells. Overall, a woman’s lifetime risk of developing ovarian cancer is considered to be about 1.3 percent, but this risk can increase several fold due to age, family history and certain genetic mutations. This is why timely identification becomes very important.

Why is early detection so difficult?

The problem is that in the early stages, ovarian cancer gives such symptoms which women often ignore, considering them a minor problem. This is why, according to the Mayo Clinic, about 75 percent of cases are detected in stage 3 or 4, when the cancer has spread beyond the ovary. Because the initial symptoms usually appear like flatulence, early filling of stomach, mild stomach pain or changing digestive habits, which are often dismissed as normal. That’s why identification happens late. On top of that, there is no regular screening test available for this disease.

Why is ovarian cancer detected so late?

The ovaries are deep within the body, hidden behind many organs. Small tumors are not easily felt and early cancer often does not cause any obvious symptoms. By the time symptoms start appearing, the disease has spread many times. For this reason, only 20 to 25 percent of patients’ cancer is caught in the early stages. As the disease progresses, the chances of survival decrease significantly.

What does Mayo Clinic’s new research say?

An important Mayo Clinic study came out this year, showing that the cells lining the fallopian tubes, which are now believed to be the initial source of ovarian cancer, begin to show subtle changes in the very early stages of the disease. The woman involved in the study was only 22 years old, but she had genetic mutations that increase the risk of cancer. The scan showed only a simple cyst, but on deeper testing, pre-cancerous changes were found in the cells.

Which common symptoms can be early signs of ovarian cancer?

Experts say that the symptoms which most women dismiss as minor problems, can actually be warning signs. In this-

• persistent bloating or heaviness in the stomach
• Feeling full after eating something
• Mild pain in the lower abdomen or pelvic area
• back pain, especially lower back
• Constipation, diarrhea or change in urinary habits
• Fatigue, weakness, sudden change in weight

Because these symptoms seem like everyday problems, it is very easy to take them lightly. But if these persist for two-three weeks continuously, it is necessary to consult a doctor.

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Disclaimer: This information is based on research studies and expert opinion. Do not consider this as a substitute for medical advice. Before adopting any new activity or exercise, please consult your doctor or relevant specialist.

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Metabolic Syndrome: A recent research conducted in India has given a big warning. In this research, it has been found that the risk of gynecological cancer i.e. cancer of reproductive organs in women with metabolic syndrome is much higher than that of normal women. These include cancer of endometrial, ovary, cervix, vagina and vulva. In such a situation, let us now tell you how the risk of cancer is increasing in women with metabolic syndrome and what has been revealed in the research.

What is metabolic syndrome?

Metabolic syndrome is a group of health problems that increase the risk of heart problems, stroke and type 2 diabetes. It is diagnosed when a woman has at least three symptoms. These symptoms include high blood pressure, high blood sugar, obesity, low cholesterol and increased triglycerides. Experts say that the problem of cancer caused by metabolic syndrome is also increasing among the youth, especially those women who have polycystic ovary syndrome are at higher risk.

What is the connection between metabolic syndrome and cancer?

This research has been done by scientists from Indian Council of Medical Research-National Institute of Reproductive and Child Health Research, Amrita Hospital in Kochi and MS Ramaiah University of Applied Sciences. It is based on a meta-analysis of 25 research from many countries including India, United States, China, United Kingdom and South Korea. It has come to light that the risk of cancer is much higher in women with metabolic syndrome. It has been seen in research that the risk of endometrial cancer increases almost two times, the risk of ovarian cancer increases three times and the risk of cervix cancer increases almost two times. Apart from this, cross sectional and cohort studies have also found increased risk of all types of gynecological cancers, which makes it clear that metabolic syndrome is an important factor in reproductive organ cancer in women.

Why does the risk of cancer increase?

According to this research, insulin resistance, obesity and chronic inflammation due to metabolic syndrome create an environment in the body that promotes cancer. At the same time, high insulin level causes hormonal imbalance and accumulation of fat in the reproductive organs affects the health of the cells. Apart from this, according to WHO-IARC’s GLOBOCAN 2022 report, about 1.47 million gynecological cancer cases have been registered worldwide. The most common cancers found in India are cervix and ovary cancer. In which about 1.27 lakh cases of cervix cancer were reported in 2022, while in that year 80,000 women lost their lives due to this type of cancer.

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Disclaimer: This information is based on research studies and expert opinion. Do not consider this as a substitute for medical advice. Before adopting any new activity or exercise, please consult your doctor or relevant specialist.

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Cause of ovarian cancer: Many times it is the biggest key to saving life, identifying the disease in time. But some diseases are such that it keeps on growing quietly and by the time it is revealed, it is too late. The ovary’s high-grade serous carcinoma (HGSC) is one such cancer, which is considered one of the most deadly forms in women. However, now scientists have recognized its root.

A major cause of death in women

Ovary cancer comes at number six in terms of cancer deaths in women. Most women do not live more than five years after its diagnosis. The reason is that in the initial stage, its symptoms are almost negligible and there are no reliable tests for it.

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What is the root of cancer

Scientists had been doubting for a long time that HGSC begins not actually in the ovaries, but in the fallopian tube. But where and how exactly, it was not clean. But research by Dr. Alexander Nikitin of Cornell University revealed that a particular type of cell of fallopian tube, pre-cyliened tubal epithelial cells, makes the real start of this cancer. These cells are the transition stage between stem cells and a fully developed ciliated cell.

Cancer is caused by pre-cylinder cells

Earlier it was believed that stem cells are responsible for this cancer. But in this research, scientists found that when two important genes that prevent cancer, TP53 and RB1 were locked in stem cells, they did not become cancerous, but died. Conversely, when these genes were closed in pre-cylindered cells, cancer started to form.

Successful experiment on mice

Scientists, using gene editing techniques, have silenced these genes in individual cells of the fallopian tube of mice. The result was clear, cancer developed only in pre-cylindered cells.

What is the new key to identifying cancer

Research also revealed that a gene named KRT5 is quite active in pre-cylinder sales. When TRP53 and RB1 were closed in high levels of this genes, high-grade ovary cancer in mice quickly developed. It became clear that these sales are the root of cancer.

Future possibilities

• This discovery can open many new possibilities
• Early Identification: Pre-cylocated cells can be detected before it becomes cancer.
• New treatment: Cancer can be prevented from starting by target
• Better Test: Risk can be detected in the initial stage using genes like KRT5 as a marker.

This study is on mice, but the structure of the fallopian tube of humans is quite similar. This discovery can be strengthened by further research on human tissue. If these results are also proved in humans, then it can be a big win in the war against ovary cancer.

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Disclaimer: Some information given in the news is based on media reports. Before implementing any suggestion, you must consult the concerned expert.

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Ovarian cancer symptoms: When a teenager was ignored as common problems related to menstruation, no one had thought that a deadly disease could be hidden behind it, ovarian cancer. A 14 -year -old girl, who hails from Derbyshire, England. Something similar has happened to him. This story is a warning for every parent that never take the health of children lightly. His mother Lisa is appealing to every parent today to ask questions, ask for answers from the doctor and understand the suffering of children. Because sometimes pain is not just pain, it can also be a knock of a serious illness.

Let me tell you, 14 -year -old Easy Pickering initially caused normal problems like stomach pain, back pain and vomiting. The family felt that these symptoms are probably of appendicitis. When Easy was rushed to the hospital, the doctors sent him back with antibiotics and considered it a problem related to periods. But the worry of mother Lisa Pickering did not diminish. Easy’s health deteriorated and finally on March 17, he underwent emergency surgery, which brought some complications and also needed to offer blood. After surgery, it was found that Easy has ovarian cancer. A disease that usually occurs after the age of 40 and is often seen after menopause.

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Easy treatment and his mother’s appeal

According to the information, more than half of ovarian cancer cases are found in women above 63 years of age. In such a situation, it is a very worrying matter to find this disease in a 14 -year -old girl. Easy chemotherapy started from 25 April, which she is taking for 5 days, three months a week. Staying out of school, now Easy is focusing on his health and his parents are taking full care of it. After going through this experience, Ezi’s mother Lisa has raised an important question, “Should girls not get the facility of some investigations with first periods?” He believes that if the doctor took his words seriously, it would not have been so late.

What are the stage of ovarian cancer?

According to doctors, it is possible to stage ovarian cancer completely only after surgery. However, it has four main stages.

Stage 1: Cancer is limited to ovary or failopian tube only.

Stage 2: Cancer has spread to pelvic organs.

Stage 3: Cancer spreads to the surfaces outside the abdomen or lymph nodes.

Stage 4: This stage is the most serious, in which cancer spreads to the remote organs of the body like liver or lungs.

Symptoms of ovarian cancer

Stomach swelling

Stomach or pelvis

Nickel

Digestive or defecation changes

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Disclaimer: Some information given in the news is based on media reports. Before implementing any suggestion, you must consult the concerned expert.

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