Pancreas cancer is counted among the most dangerous and deadly cancers in the world. This disease progresses so silently that by the time its symptoms are clearly visible, it is often too late. This is the reason why about 90 percent of patients suffering from this cancer die within five years.

This cancer has remained a big challenge for doctors and scientists for a long time. Neither is it detected early nor are there very effective options for its treatment. But now, after several decades of despair, some new research has shown a new light of hope. In recent years, scientists have been trying to understand how to prepare the body’s own immune system in such a way that it can fight cancer on its own. In this direction, enthusiasm has increased regarding treatment based on vaccine and immunotherapy.

Successful experiment on rats, hope for humans

Spanish scientists have recently developed a new combination therapy method, which completely eliminated pancreas cancer tumors from the body of rats in the laboratory. Although this research has not yet been tried on humans, its results are so positive that scientists have started feeling that in future this method can help in saving the lives of patients.

Earlier, in America too, scientists had conducted initial human trials of mRNA-based personalized pancreas cancer vaccine, in which good results were seen in some patients. These two studies together have indicated that vaccine-based treatment can bring a big change in the future.

How does this new therapy work?

This study conducted in Spain was conducted by scientist Mariano Barbaside and his team from the Spanish National Cancer Research Center (CNIO). This treatment is not based on any one medicine, rather three different methods have been used together. The first of which is advanced immunotherapy, through which the body’s immune system is strengthened. After this, the second cancer vaccine, which teaches the immune system to recognize cancer cells.

The third one is checkpoint inhibitors, which remove the brakes on the immune system and allow it to freely fight cancer. By combining these three, scientists broke the protective shield around the cancer, so that T-cells could attack the cancer and the tumor could not return. Experts believe that using more than one method together makes treatment more effective than giving only one medicine.

Statistics show the seriousness of the disease

According to the World Health Organization’s cancer agency, about 5.1 lakh new cases of pancreas cancer were reported worldwide in 2022. In the same year, about 4.6 lakh people died due to this cancer. The situation is worrying in India also. 13,661 new patients and 12,759 deaths were recorded here. These figures clearly show how quickly this cancer kills.

KRAS gene and the problem of drug resistance

In about 90 percent of pancreas cancer cases, a gene called KRAS is defective (mutated). For a long time, no drug was available that could target this gene. For about 50 years, treatment mainly depended on chemotherapy. In 2021, drugs targeting KRAS were approved for the first time, but the problem was that within a few months the tumor developed resistance against those drugs.

Barbasid and his team found a unique solution to this problem. They blocked the KRAS signaling pathway at not one, but three different places. Although the results are very encouraging, the scientists themselves are cautious. Barbacid has clearly said that we are not yet ready to try this triple therapy on humans. He said that more research, safety testing and preparation is needed before starting human trials.

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Disclaimer: This information is based on research studies and expert opinion. Do not consider this as a substitute for medical advice. Before adopting any new activity or exercise, consult your doctor or relevant specialist.

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Early Signs Of Pancreatic Cancer: A Spanish research team has claimed that it has developed a treatment that can completely eliminate the most dangerous form of pancreatic cancer in lab rats. This cancer is counted among the most deadly cancers in the world. This study was conducted under the leadership of scientist Mariano Barbacid at Spain’s National Cancer Research Center (CNIO). Let us tell you what claims have been made regarding this.

What has come out in the research?

According to the research, scientists used a new combination of three medicines, which completely destroyed the pancreatic tumors present in rats. The most important thing was that after the treatment there were no signs of cancer returning again. In this research that lasted for six years, it was also found that the treatment had very few side effects on the animals. Pancreatic cancer, especially pancreatic ductal adenocarcinoma, is considered fatal because it is highly resistant to treatment and is often detected late. Usually, treatment based on a single drug fails because cancer cells adapt rapidly.

What does the researcher say?

This new therapy from CNIO takes a different approach. In this, by combining not one but three medicines, many life-saving processes of cancer were stopped simultaneously. Researchers say that due to this, cancer cells do not get a chance to remodel themselves. Experiments conducted in the lab found that tumors in rats suffering from advanced stage pancreatic cancer completely disappeared. Despite long-term monitoring, the tumor did not recur, which is considered extremely rare in this disease.

still waiting for humans

This study has been published in the prestigious journal Proceedings of the National Academy of Sciences (PNAS). Reviewers have particularly highlighted the treatment’s long-term effects and low side effects. Cancer experts say that such results without cancer returning are very unusual in pancreatic cancer research. After this discovery, there was excitement as well as skepticism on social media. Some people called it a big leap towards treatment, while others raised questions on calling it a ‘cure’. Experts say that after the success in rats, trials on humans and a long process still remain.

What is pancreatic cancer?

Pancreatic cancer is a disease that begins with abnormal growth of cells in the pancreas. The pancreas is located behind the lower stomach and produces enzymes that aid digestion and hormones that control blood sugar. Its most common type is pancreatic ductal adenocarcinoma.

This cancer is often not caught in the early stages because the symptoms appear late. Its symptoms include pain in the stomach or back, weight loss, loss of appetite, jaundice, dark urine, fatigue and sudden increase in diabetes. If such symptoms appear, contact the doctor immediately. In 80 to 85 percent of cases, symptoms appear late and only 10 percent of patients are able to survive for 5 years.

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Generally, we associate any serious disease with pain, severe discomfort or sudden worsening of the condition. We think that when something goes wrong with the body, the body itself will warn us. But there are many types of cancer which prove this thinking completely wrong. These cancers keep growing silently inside the body for years. Neither severe pain, nor any major symptoms, nor anything that would force a person to go to the doctor immediately and by the time these symptoms become clearly visible, it is often too late.

The most dangerous form of cancer is not its speed, but its silence. Many times cancer is present in the body, but both the patient and the doctor are unable to realize it. In such a situation, let us know which cancers make their victims very silently.

Which cancers hunt their victims very silently?

1. Ovarian Cancer – Ovarian cancer has long been considered a silent killer. The initial symptoms of this cancer are very mild and confusing, such as slight bloating, feeling full quickly, slight discomfort in the lower abdomen or pelvis. Most women ignore these symptoms considering them as gas, indigestion or normal periods problem. For this reason, in almost two-thirds of the cases, ovarian cancer is detected in the third or fourth stage, when the disease has spread to the stomach.

2. Pancreatic Cancer – If we talk about the most deadly silent cancers, then pancreatic cancer comes at the top. Only in less than 15 percent of cases this cancer is caught in the early stages. Most patients come when the cancer has spread. In the beginning there is neither pain, nor jaundice, nor any serious digestive problem. By the time symptoms appear, such as severe pain, weight loss or jaundice, the time for surgery has passed. For this reason, this cancer can be cured in very few cases.

3. Lung Cancer – Lung cancer is the leading cause of cancer deaths in the world, yet it too often grows silently. Its initial symptoms are mild but long lasting cough, slight breathlessness, constant fatigue, people who smoke consider these symptoms to be normal. Even the family members do not show much seriousness. The result is that about 70 percent of the patients reach the doctor in the third or fourth stage.

4. Colorectal cancer – Intestinal cancer can remain without any problem for a long time. Its initial signs are very minor. Like a little blood in the stool (which is not visible), anemia due to iron deficiency, slight change in defecation habits. People consider them as piles, weakness or effect of age. Whereas the truth is that if diagnosed on time, this cancer can be completely cured.

5. Breast Cancer – Breast cancer is increasing rapidly in India, but it does not cause pain in its initial stages. Often women think that if there is no pain, then nothing serious will happen. But in India, almost half of the patients are in advanced stage. In 8–10 percent of patients, cancer has already spread in the body. Ignoring lumps, skin changes or discharge from the nipple can prove costly.

6. Gallbladder Cancer – Gallbladder cancer is increasing rapidly in North India. Initially its symptoms seem like gallstones, mild stomach pain, indigestion. Patients and sometimes even doctors consider it to be a normal stone. By the time jaundice or severe pain occurs, in 70–80 percent of cases the cancer has spread significantly.

Disclaimer: This information is based on research studies and expert opinion. Do not consider this as a substitute for medical advice. Before adopting any new activity or exercise, please consult your doctor or relevant specialist.

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Pancreatic Cancer Causes: Nowadays people have become so busy in their busy lives that they do not get time to pay attention to their diet and other daily lifestyle. Due to this, cases like cancer, stroke, heart attack have increased much more than before. The most dangerous thing in this is cancer. In which pancreatic cancer, often known as the silent killer, is a very dangerous and rapidly spreading disease. The biggest challenge for you in detecting it is that you are not able to catch it easily in the initial stage, because its initial symptoms are not special.

Common signs of this disease include stomach pain, jaundice and sudden weight loss. But many recent researches on this show that some problems occurring in other parts of the body, especially in the legs, can be its early warning signs. Let us tell you which of its symptoms we start seeing from the very beginning.

How to know its symptoms

In many patients, symptoms like pain, swelling, redness or warmth in the legs appear before stomach related symptoms. These small problems are often ignored, but they can point towards pancreatic cancer. If timely attention is given, the chances of early diagnosis and better treatment increases. First of all, you need to note that if there is persistent or unexplained pain in the legs, then it can be a sign of deep vein thrombosis i.e. blood clot formation in the deep veins. According to the American Cancer Society, in case of pancreatic cancer, the blood clotting process of the body gets affected, due to which the risk of DVT increases.

Do not take such pain lightly, because it can be a serious problem due to pressure in the veins, swelling or stoppage of blood flow. If we talk about other symptoms, sudden swelling in one or both legs without any reason can also be a cause for concern. In cancer patients, this often occurs due to pressure on the nerves by a blood clot or tumor. If there is pain, redness or warmth along with swelling, you should immediately consult a doctor. Apart from this, the feet become dark red in color and the warmth in the feet increases.

Why is it important to know the symptoms

Now the question comes that why and how important is it to know about its symptoms. So the most important thing is that pancreatic cancer is often caught late, by the time the disease has progressed significantly. In such a situation, these initial symptoms related to feet can help in reaching the doctor in time. If someone suddenly and without any reason is feeling pain, swelling, redness or warmth in the feet, then do not ignore it. By getting timely treatment, identification of the disease becomes easier and the patient can get better treatment options.

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One of America’s most popular and well-known judges, Frank Capriyo died at the age of 88. He died of Panctivity Cancer. Judge Capriyo was famous not only for his decisions but also for his kind nature and welfare decisions. His death made his fans very grieved in America and all over the world.

Life and career

Judge Capriyo was known worldwide through a reality show called “Catch in Providence”. In this show, he heard traffic and small cases in his unique and kind style. His style was always full of humanity and understanding. A video of him became very viral on social media, in which he waived the invoices of an elderly man’s overspeed. He said that this was the first time that the elderly drove the car at a speed higher than the limit. His sympathy and kindness were clearly visible in this small decision.

How dangerous is pancreatic cancer

Judge Frank Capriyo died due to pancreatic cancer. It begins in cancer pancreas, which is an important organ inside the stomach and helps in digestion and insulin production.

Difficulty in identification

Pancreatic cancer often shows no obvious symptoms in the early stage. Therefore, it often comes to know when the disease has increased considerably.

Rapid spread cancer

This cancer can spread quickly and reach nearby organs such as liver, stomach and blood cells. This is why it becomes difficult to treat.

High mortality rate

The chances of surviving due to pancreatic cancer are very low. Most patients do not survive within 5 years of diagnosis, especially if the cancer is in advance stage.

Symptoms and signs

The main symptoms are stomach or back pain, weight phenomenon, yellowing of skin and eyes, loss of appetite. When it increases very much, the health of the patient deteriorates quickly.

Cure challenges

Surgery, chemotherapy and radiotherapy are the main options for treatment. But it is difficult to remove cancer in advance stage.

Pancreatic cancer is considered one of the most dangerous cancer in the world. Its initial identity makes it more serious to spread difficult and rapidly. Timely investigation, focusing on health and not ignoring the symptoms is the biggest way to prevent it.

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Pancreatic Cancer Symptoms: Some diseases in the world are so dangerous that only after hearing about them, the hair stands up. Pancreasic cancer is one of them, which is called ‘silent killer’. This disease often increases gradually in the body without any clear symptoms.

A recent research in Miami, USA, has warned that drinking regular and excessive amounts of alcohol can increase the risk of this deadly disease manifold. Scientists believe that, they have discovered a major cause behind the disease and a possible way to stop it.

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Alcohol and pancreas

Research found that drinking high amounts of alcohol damages the cells of pancreas that form digestive enzymes. This damage causes swelling in the limb. The pancreas plays an important role in digesting food and controlling blood sugar. When there is frequent swelling in it, it can turn into a pre-cancerous wound, which can later take the form of pancreatic cancer.

How does the risk of cancer increases?

According to scientists, it is necessary to change not only swelling, but also a particular gene change to become cancer. This controls the growth of gene cells. Experiments found that when alcohol and a pro-inflammatory are found, it causes symptoms like alcohol pancreatitis, which can cause cancer.

Search for ‘Master Controller’ gene

Researchers found that another gene creb acts like a ‘master controller’ in this entire process. This transforms healthy pancreas cells permanently unusual and pre-cancer cells. When this gene was deactivated, pre-cancer and cancerous wounds stopped in the pancreas.

Which people are more in danger?

• People over 65 years of age
• Whose family has a history of pancreatic cancer
• Chronic pancrectitis
• Smokers, people suffering from overweight or obesity
• Diabetes patients
• Excessive consumption of red and processed meat
• O, A, B, AB may also vary the risk on the basis of blood group

How to see the initial symptoms

• A sudden weight
• Persistent fatigue
• Abdominal pain
• Digestive change
• Embellish of skin and eyes

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Disclaimer: Some information given in the news is based on media reports. Before implementing any suggestion, you must consult the concerned expert.

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Cancer, a disease whose name is heard in the mind. Life seems to be shattering. If this disease is detected in time, treatment is also possible in many cases. But if this disease is not treated, then it can be even more dangerous. Rapidly can affect the important organ of the body. How can the cancer spreads in the body when not undergoing treatment, let us know …

How fast does cancer spreads in the body?

Many factor are responsible for the growth of cancer in the body. For example, what kind of cancer is there, cancer diagnos stage, genetic region, patient’s age, health and immune system etc. According to researchers, some cancers spread rapidly in the body. Such as pancreatic cancer, small cell lung cancer, some brain tumors can not be treated rapidly in weeks or months if they are not treated. Soon other parts of the body can be engulfed. According to a study, there are no symptoms in the beginning of pancreatic cancer. It quietly does home in the body. When the symptoms come out, it has reached the advance stage.

The speed of these cancer is slow

However, some cancers grow slow. Similar is seen in prostate cancer. This cancer can take many years to grow. There is no symptom or any serious problem of this cancer in the elderly. Similarly, some breast cancer also spreads slow. In these, the speed of breast cancer due to hormones is slow. If they are diagnosed early, then treatment is also possible.

Isn’t slow cancer dangerous?

If cancer is growing slow in the body, then it is not dangerous. Such thinking can be overwhelming. Slow -growing cancer can also be dangerous over time. Due to rapid increase in cancer cells in the body, they enter the bloodstream along with damaging nearby tissues. Due to which other organ of the body can be engulfed. According to the study, if the cancer is not treated, it can reach liver, langs and brain with lymph nodes. This process is called metastasis. Once the cancer is spread in the body, it becomes free to treat and control it.

Status on not getting treatment

The condition of the cancer patient becomes critical due to not getting treatment. The situation goes on deteriorating with passing time. There is unbearable pain, which is to control. Infection, organ failure positions with blee ding.

Also read: Which vitamin deficiency causes depression, how to do it right?

Disclaimer: Some information given in the news is based on media reports. Before implementing any suggestion, you must consult the concerned expert.

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