How Gene Therapy Reduces LDL Cholesterol: Scientist has raised a big hope for crores of people suffering from heart diseases and bad cholesterol. Scientists claim that such a treatment is now being developed in which bad cholesterol can remain under control for a long time by taking gene therapy just once. If its results are successful in the upcoming larger trials, then in future many patients may not need to take cholesterol medicines throughout their life.

Does it really work?

Scientist has done research on a new gene therapy Verv-102, the results of which have been published in a reputed medical journal. In this study, it was found that this therapy was successful in reducing the bad LDL cholesterol present in the body by 62 percent. This research was done on those patients who had high cholesterol problem since birth or had increased risk of heart disease at an early age. A total of 35 patients were included in the initial trial. Scientists observed that in patients who were given higher doses, LDL cholesterol levels decreased by an average of 78 mg/dl. The most important thing was that in many patients its effect persisted for a year.

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Very important for heart diseases

Dr. Ambuj Roy, Cardiology Professor, All India Institute of Medical Sciences, Delhi, has described this study as very important in the field of treatment of heart diseases. He says that this research proves that through in-vivo base editing of PCSK9 gene, LDL cholesterol can be reduced in the body for a long time. If its long-term safety is proved to be completely safe in the future, then it can bring a big change in the treatment of heart diseases.

How does gene therapy work in the body?

According to the scientist, this therapy permanently switches off the gene named PCSK9 present in the liver. This gene plays an important role in controlling cholesterol levels in the body, for this advanced base editing technology has been used, which is considered a more accurate and modern method of gene editing.

How is bad cholesterol dangerous for us?

Worldwide, high LDL cholesterol is counted among the biggest causes of heart attack, stroke and blockage. Many patients are not completely safe despite taking medicines. In such a situation, scientists hope that this new therapy can open the way for one-time treatment in future. It is a matter of relief that no major security threat was revealed in the initial trials. The research-related pharmaceutical company has said that it will start the second phase clinical trials of Verv-102 this year.

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Disclaimer: This information is based on research studies and expert opinion. Do not consider this as a substitute for medical advice. Before adopting any new activity or exercise, please consult your doctor or relevant specialist.

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