By Admin 
How Radiation Therapy Helps In Bladder Cancer Treatment: Surgery is considered one of the most effective methods in the treatment of bladder cancer, but in many patients there is a risk of the disease returning even after the operation. This challenge is especially seen in high-risk muscle-invasive bladder cancer patients. In such a situation, a new study has indicated that radiation therapy given after surgery can prove beneficial for patients and can reduce the risk of cancer returning.
How does radiation therapy work?
Research published in the Journal of Clinical Oncology has revealed the findings from a Phase-3 clinical trial. Researchers found that patients who underwent radiation therapy after surgical removal of the bladder and chemotherapy were less likely to have cancer return to the same area. According to the study, better disease control can be achieved with radiation therapy, although the improvements shown in overall survival rates and disease-free duration were not considered completely significant.
Who were included in the research?
This test was conducted in four academic medical centers in India, which included 153 patients suffering from non-metastatic muscle-invasive bladder cancer. Of these, 71 percent patients were given chemotherapy before surgery, while about 20 percent patients received chemotherapy after surgery. After this, some patients were given radiation therapy, while other patients were kept only under observation.
What was its result?
Radiotherapy is started within eight weeks of surgery or the last chemotherapy session. After monitoring the patients for about 47 months, the researchers found that the two-year rate of cancer not coming back locally or in nearby areas was 87.1 percent in the radiation group, while this figure was 76 percent in the observation-only group. The researchers said that adjuvant pelvic intensity-modulated radiation therapy improved local control in high-risk urothelial muscle-invasive bladder cancer patients without a significant increase in serious adverse effects. This is the reason why experts are considering it an important part of the treatment given after surgery.
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Disease-free survival 71.6 percent
It was also observed in the study that the disease-free survival in the patients who received radiation was 71.6 percent, whereas in the other group it was 58.7 percent. Similarly, bladder cancer-specific survival and overall survival figures were also found to be better in the radiation group. However, these results were not considered conclusive from statistical form. The most important thing was that in the patients who were given pelvic radiation, cancer recurred at the local or regional level only in 7.9 percent of the cases. Whereas in the monitored group this rate was recorded at 25.6 percent. This indicates that radiation therapy can play an important role in preventing cancer from coming back in the same area.
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Disclaimer: This information is based on research studies and expert opinion. Do not consider this as a substitute for medical advice. Before adopting any new activity or exercise, please consult your doctor or relevant specialist.
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